NewEast/FGFR1 (R78H) [26251][100ul]/26251

CatalogNumber:  26251

GeneSymbol:  FGFR1,BFGFR,CD331,CEK,FGFBR,FLG

Description:  Anti-FGFR1(R78H)MouseMonoclonalAntibody

Background:  TheproteinFGFR1ishighlyconservedbetweenmembersandthroughoutevolution.ThisparticularfamilymemberofFGFR1bindsbothacidicandbasicfibroblastgrowthfactorsandisinvolvedinlimbinduction.MutationsofFGFR1proteinhavebeenassociatedwithPfeiffersyndrome,Jackson-Weisssyndrome,Antley-Bixlersyndrome,osteoglophonicdysplasia,squamouscelllungcancerandautosomaldominantKallmannsyndrome.

Immunogen:  AsyntheticpeptidefromtheinternalregionofFGFR1whichincludesthemutationofR78H,humanorigin.

Applications:  ELISA,WB,IHC

RecommendedDilutions:  ELISA:1:1000-1:2000WB:1:500-1:1000IHC:1:50-1:100

Concentration:  0.5mg/ml

Host:  Mouse

Format:  Liquid

Clonality:  Monoclonal

Isotype:

Purity:  Purifiedfromascites

Storagebuffer:

Preservative:  no

Constituents:  PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol

SpeciesReactivity:  RecognizesR78Hmutant,butnotwild-typeFGFR1ofvertebrates.

StorageConditions:  Storeat-20°C.Avoidfreeze/thawcycles

DownloadDatasheet:

Westernblot:

WesternblotanalysisofrecombinantFGFR1(R78H)andwildtypeproteins.PurifiedHis-taggedFGFR1(R78H)protein(aa22-376,~45KDa,lane2)andcorrespondingwildtypeprotein(lane1)wereblottedwithanti-FGFR1(R78H)monoclonalantibody(Cat.#26251).

Immunofluorescence:

ImmunofluorescenceofcellsexpressingFGFR1proteinswithanti-FGFR1(R78H)antibody.HEK293TcellsweretransfectedwithpCDNA3-GFP-FGFR1(WT)plasmid(leftcolumn)orpCDNA3-GFP-FGFR1(R78H)plasmid(rightcolumn),thenfixedandstainedwithanti-FGFR1(R78H)monoclonalantibody(Cat.#26251).

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