CatalogNumber: 26902 |
GeneSymbol: Gna13 |
Description: Anti-ActiveGα13-GTPMouseMonoclonalAntibody |
Background: HeterotrimericGproteinsareessentialcellularsignaltransducers.Gα13isoneoftheGproteinsthatcouldmediatecellmigrationandangiogenesis.OtherbiochemicalandphysiologicalfunctionsofGα13arebeingexplored. |
Immunogen: RecombinantfulllengthactiveGα13protein |
Applications: IP,IHC |
RecommendedDilutions: 1µgfor1~2mgtotalcellularproteinsforIP; 1:100dilutionforIHC |
Concentration: 1mg/ml |
Host: mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG2b |
Purity: Purifiedfromascites |
Storagebuffer: |
Preservative: no |
Constituents: PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol |
SpeciesReactivity: Anti-activeGα13monoclonalantibodyrecognizesactiveGα13ofvertebrates. |
StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles |
DownloadDatasheet: |
Immunoprecipitation/Westernblot: |
IP/WBanalysisofactiveGα13proteins.PurifiedGα13proteinsweretreatedwithGDP(lane1)orGTPGTPγS(lane2).Afterimmunoprecipitationwithanti-activeGα13-GTPmousemonoclonalantibody(Cat.#26902),theseproteinswereseparatedbySDS/PAGEandwesternblottedwithanti-Gα13mousemonoclonalantibody(Cat.#26004). | |
Immunohistochemistry: |
StainingofMEFcells(treatedwithPDGF)withanti-Gα13-GTPmonoclonalantibodyshowingthelocalizationofGα13-GTPintheleADIngedgeofmigratingcells. |
RelatedProducts | |||||
Catalog# | Name | Size | Price | DataSheet | |
13ActivationAssayKit">80401 | Gα13ActivationAssayKit | 20assays | $637 | ||
13-GTP">26902 | ActiveGα13-GTPMonoclonalAntibody | 30μL | $495 | ||
13MouseMonoclonalAntibody">26004 | Anti-Gα13MouseMonoclonalAntibody | 100μL | $239 | ||
13RabbitPolyclonalAntibody">21005 | Anti-Gα13RabbitPolyclonalAntibody | 100μL | $219 |
Publications:1. Resistancetoinhibitorsofcholinesterase-8A(Ric-8A)iscriticalforgrowthfactorreceptor-inducedactincytoskeletalreorganization JBiolChem.2011Sep2;286(35):31055-61 | 2. AgoNISTactivationoftheGprotein-coupledreceptorGPR35involvestransmembranedomainIIIandistransducedviaGalphaandbeta-arrestin-2 BrJPharmacol.2011Feb;162(3):733-48 | 3. Gα12/13inhibitionenhancestheanti-cancereffectofbortezomibthroughPSMB5downregulation Carcinogenesis(2010) | 4. SuppressionoftumorangiogenesisbyGalpha(13)haploinsufficiency JBiolChem.2009Oct2;284(40):27409-15 | 品牌介绍
NewEastBio我们已经开发了一项专有技术(正在申请专利),以生产与GTP结合的G蛋白的单克隆抗体。抗体应比结合GDP的蛋白更好地识别纯化的结合GTP的G蛋白(至少10倍)。我们可以利用该技术为您的特殊G蛋白生成抗体。活性G蛋白抗体的成本为10,000美元。但是,我们保留将抗体作为我们的产品销售的权利。
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