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NewEast/Rac1 [26005][100µL]/26005,NewEastBio,,NewEastBio,NewEast Biosciences,+,,Array.Array.Array蚂蚁淘厂家直采.
主营:专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。
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NewEast/Rac1 [26005][100µL]/26005

NewEast/Rac1 [26005][100µL]/26005
  • NewEast/Rac1 [26005][100µL]/26005
商品介绍

CatalogNumber:  26005
GeneSymbol:  RAC1
Description:  Anti-Rac1MouseMonoclonalAntibody
Background:  SmallGTPasesareasuper-familyofcellularsignalingregulators.RacbelongstotheRhosub-familyofGTPasesthatregulatecellmotility,celldivision,andgenetranscription.Inmammals,therearethreeRacgenes:Rac1,Rac2andRac3.GTPbindingincreasestheactivityofRac,andthehydrolysisofGTPtoGDPrendersitinactive.GTPhydrolysisisaidedbyGTPaseactivatingproteins(GAPs),whileexchangeofGDPforGTPisfacilitatedbyguaninenucleotideexchangefactors(GEFs).
Immunogen:  RecombinantfulllengthproteinofRac1
Applications:  ELISA,WB,IHC
RecommendedDilutions:  ELISA1:1000-1:5000WB1:1000-1:2000
Concentration:  1mg/ml
Host:  mouse
Format:  Liquid
Clonality:  Monoclonal
Isotype:  IgG
Purity:  Purifiedfromascites
Storagebuffer:
Preservative:  no
Constituents:  PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol
SpeciesReactivity:  Rac1antibodyrecognizesRac1fromvertebrates.
StorageConditions:  Storeat-20°C.Avoidfreeze/thawcycles
DownloadDatasheet:  
Westernblot:  
WesternblotanalysisofRac1proteins.MEFwhole-celllysatewasusedforwesternblots.Themonoclonalanti-Rac1antibodywaspre-incubatedwithout(lane1)orwith(lane2)theantigenprotein(Rac1)toshowthespecificity.
 
RelatedProducts
Catalog#NameSizePriceDataSheet
80501RacActivationAssayKit 20assays $637   
26903ActiveRac1-GTPMonoclonalAntibody 30μL $495   
26005Anti-Rac1MouseMonoclonalAntibody 100μL $239   
21003Anti-Rac1RabbitPolyclonalAntibody 100μL $219   
品牌介绍

NewEastBio我们已经开发了一项专有技术(正在申请专利),以生产与GTP结合的G蛋白的单克隆抗体。抗体应比结合GDP的蛋白更好地识别纯化的结合GTP的G蛋白(至少10倍)。我们可以利用该技术为您的特殊G蛋白生成抗体。活性G蛋白抗体的成本为10,000美元。但是,我们保留将抗体作为我们的产品销售的权利。

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Publications:
1.  Phosphorylationofα-tubulinbyproteinkinaseCstimulatesmicrotubuledynamicsinhumanbreastcellsCytoskeletonVolume71,Issue4,pages257–272,April2014
2.  ImmunofluorescenceandConfocalMicroscopyofNeutrophilsNeutrophilMethodsandProtocolsMethodsinMolecularBIOLOGyVolume1124,2014,pp251-268
3.  Alinkbetweenthenuclear-localizedsrGAP3andtheSWI/SNFchromatinremodelerBrg1MolecularandCellularNeuroscienceVolume60,May2014,Pages10–25
4.  SHP2PhosphatasePromotesMastCellChemotaxistowardStemCellFactorviaEnhancingActivationoftheLyn/Vav/RacSignalingAxisTheJournalofImmunologyApril14,20141301155
5.  ROBO1,atumorsuppressorandcriticalmolecularbarrierforlocalizedtumorcellstoacquireinvasivephenotype:StudyinAfrican-AmericanandCaucasianprostatecancermodelsInternationalJournalofCancerVolume135,Issue11,pages2493–2506,1December2014
6.  TranscriptionfactorsNRF2andnf-kbarecoordinatedeffectorsoftheRHOfamily,GTPbindingproteinrac1duringinflammationJBiolChem.2014May30;289(22):15244-58
7.  CanonicalandNon-canonicalG-proteinSignalingHelpsCoordinateActinDynamicstoPromoteMacrophagePhagocytosisofZymosanMolCellBiol.2014Nov15;34(22):4186-99
8.  p53DownRegulatesPDGF-InducedFormationofCircularDorsalRufflesinRatAorticSmoothMuscleCellsPLoSOne.2014Sep23;9(9):e108257
9.  LPA-mediatedmigrationofovariancancercellsinvolvestranslocalizationofGαi2toinvadopodiaandassociationwithSrcandβ-pixCancerLett.2015Jan28;356(2PtB):382-91
10.  cAMPcontrolstherestorationofendothelialbarrierfunctionafterthrombin-inducedhyperpermeABIlityviaRac1activationPhysiologicalReportsPublished24October2014Vol.2no.e12175DOI:10.14814/phy2.12175
11.  CisplatinatSub-toxicLevelsMediatesIntegrinSwitchinLungCancerCellsAnticancerResearchDecember2014vol.34no.127111-7117
12.  Semaphorin-3FsuppressesthestemnessofcolorectalcancercellsbyinactivatingRac1Cancerletters.March1,2015Volume358,Issue1,Pages76–84.
13.  GeometrysensingthroughPOR1regulatesRac1activitycontrollingearlyosteoblastdifferentiationinresponsetonanofiberdiameterIntegrBiol(Camb).2014Dec24
14.  InhibitionofRac1ActivityintheHippocampusImpairstheForgettingofContextualFearMemoryMolNeurobiol.2015Jan24