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℡ 4000-520-616
℡ 4000-520-616
![NewEast/IDH1 (R132P) [26406][100ul]/26406](images/neweastbio/26406-1.jpg)
商品介绍
| CatalogNumber: 26406 |
| GeneSymbol: IDH2;D2HGA2;ICD-M;IDH;IDHM;IDP;IDPM;mNADP-IDH |
| Description: Anti-IDH1(R132P)MouseMonoclonalAntibody |
| Background: Isocitratedehydrogenases(IDH)catalyzetheoxidativedecarboxylationofisocitrateto2-oxoglutarate.MutationsaffectingArg-132aretissue-specific,andsuggestthatthisresidueplaysauniqueroleinthedevelopmentofhigh-gradegliomas.MutationsofArg-132toCys,His,LeuorSerabolishmagnesiumbindingandabolishtheconversionofisocitratetoalpha-ketoglutarate.Instead,alpha-ketoglutarateisconvertedtoR-2-hydroxyglutarate.ElevatedlevelsofR-2-hydroxyglutaratearecorrelatedwithanelevatedriskofmalignantbraintumors. |
| Immunogen: AsyntheticpeptidefromtheinternalregionofIDH1whichincludesthemutationofR132P,humanorigin. |
| Applications: ELISA,WB,IHC |
| RecommendedDilutions: ELISA:1:1000-1:5000WB:1:100-1:1000IHC:1:50-1:100 |
| Concentration: 1mg/ml |
| Host: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: |
| Purity: Purifiedfromascites |
| Storagebuffer: |
| Preservative: no |
| Constituents: PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol |
| SpeciesReactivity: recognizesR132Pmutant,butnotwild-typeIDH2ofvertebrates. |
| StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles |
DownloadDatasheet:  |
| Westernblot: |
| WesternblotanalysisofrecombinantIDH1(R132P)andwildtypeproteins.PurifiedHis-taggedIDH1(R132P)(lane1)andcorrespondingwild-typeIDH1protein(lane2)wereblottedwithanti-IDH1(R132P)monoclonalantibody(Cat.#26406). |
| Immunofluorescence: |
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 |
| ImmunofluorescenceofcellsexpressingIDH1proteinswithanti-IDH1(R132P)antibody.HEK293TcellsweretransfectedwithpCDNA3-GFP-IDH1(R132P)plasmid,pCDNA3-GFP-IDH1(WT)plasmid,pCDNA3-GFP-IDH1(R132S)plasmid,pCDNA3-GFP-IDH1(R132L)plasmid,pCDNA3-GFP-IDH1(R132G)plasmidorpCDNA3-GFP-IDH1(R132C)plasmid,thenfixedandstainedwithanti-IDH1(R132P)monoclonalantibody(Cat.#26406). |
| RelatedProducts | |||||
| Catalog# | Name | Size | Price | DataSheet | |
| 26136 | Anti-IDH1MouseMonoclonalAntibody | 100μL | $239 |  | |
| 21277 | Anti-IDH1RabbitPolyclonalAntibody | 100μL | $219 | | |
| 26081 | Anti-IDH1(R132H)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26160 | Anti-IDH1(R132S)MouseMonoclonalAntibody | 100μL | $495 | | |
| 21278 | Anti-IDH2RabbitPolyclonalAntibody | 100μL | $219 | | |
| 26084 | Anti-IDH2(R172H)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26163 | Anti-IDH2(R172K)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26164 | Anti-IDH2(R172W)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26321 | Anti-IDH2(R172G)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26165 | Anti-IDH2(R140Q)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26406 | Anti-IDH1(R132P)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26408 | Anti-IDH2(R172S)MouseMonoclonalAntibody | 100μL | $495 | | |
Publications:| 1. SpecificmonoclonalantibodiesagainstIDH1/2mutationsasdiagnostictoolsforgliomas BrainTumorPathology.January2015,Volume32,Issue1,pp3-11 | 2. MutantIDHinhibitsHNF-4αtoblockhepatocytedifferentiationandpromotebiliarycancer Nature513,110–114(04September2014) | 3. Metabolomiccomparisonbetweencellsoverexpressingisocitratedehydrogenase1and2mutantsandtheeffectsofaninhibitoronthemetabolism JournalofNeuRochemistry.Volume132,Issue2,pages183–193,January2015 | 品牌介绍
NewEastBio我们已经开发了一项专有技术（正在申请专利），以生产与GTP结合的G蛋白的单克隆抗体。抗体应比结合GDP的蛋白更好地识别纯化的结合GTP的G蛋白（至少10倍）。我们可以利用该技术为您的特殊G蛋白生成抗体。活性G蛋白抗体的成本为10,000美元。但是，我们保留将抗体作为我们的产品销售的权利。 公司介绍
产品分类
10 µg Purified G Proteins
1x96 well Biomarkers
100µL Monoclonal Antibodies
100ul Purified G Proteins
100 µL Antibodies for mutated oncogenes
96 well cAMP and cGMP EIA Kits
30 µL Active Monoclonal Antibodies
100 µL Biomarkers
30 µL Biomarkers
cAMP and cGMP EIA Kits
100 µL Polyclonal Antibodies
Antibody&Assay
20 Assays Active Assay Kits
Active Monoclonal Antibodies
Active Assay Kits
Polyclonal Antibodies
Purified G Proteins
Monoclonal Antibodies
100ul Monoclonal Antibodies
100ul Antibodies for mutated oncogenes
100 µL Monoclonal Antibodies
5x96 well cAMP and cGMP EIA Kits
96 well Biomarkers
200 µg Purified G Proteins
25 µg Purified G Proteins
30 µL Antibodies for mutated oncogenes
30 ul Active Monoclonal Antibodies
100 µg Purified G Proteins
1x96 well cAMP and cGMP EIA Kits
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总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏ 0512-67156496（苏州）
版权信息：
© 2015- 苏州蚂蚁淘生物科技有限公司 版权所有 中国
友情链接：
联系QQ:764052152
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